Mammalian tolloid proteinases: role in growth factor signalling
| Autor: | Troilo, Helen, Bayley, Christopher P., Barrett, Anne L., Lockhart‐Cairns, Michael P., Jowitt, Thomas A., Baldock, Clair |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Mammals
BMP signalling animal structures Tolloid-Like Metalloproteinases twisted gastrulation Biophysics Proteins Review Article latent TGFβ‐binding protein Substrate Specificity Transforming Growth Factor beta1 Mice Latent TGF-beta Binding Proteins embryonic structures Animals Humans Intercellular Signaling Peptides and Proteins chordin Review Articles Glycoproteins Peptide Hydrolases Signal Transduction |
| Zdroj: | Troilo, H, Bayley, C P, Barrett, A L, Lockhart-Cairns, M P, Jowitt, T A & Baldock, C 2016, ' Mammalian tolloid proteinases: role in growth factor signalling ', FEBS Letters, vol. 590, no. 15, pp. 2398-2407 . https://doi.org/10.1002/1873-3468.12287 Febs Letters |
| DOI: | 10.1002/1873-3468.12287 |
| Popis: | Tolloid proteinases are essential for tissue patterning and extracellular matrix assembly. The members of the family differ in their substrate specificity and activity, despite sharing similar domain organization. The mechanisms underlying substrate specificity and activity are complex, with variation between family members, and depend on both multimerization and substrate interaction. In addition, enhancers, such as Twisted gastrulation (Tsg), promote cleavage of tolloid substrate, chordin, to regulate growth factor signalling. Although Tsg and mammalian tolloid (mTLD) are involved in chordin cleavage, no interaction has been detected between them, suggesting Tsg induces a change in chordin to increase susceptibility to cleavage. All members of the tolloid family bind the N terminus of latent TGFβ-binding protein-1, providing support for their role in TGFβ signalling. |
| Databáze: | OpenAIRE |
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