Renal function and serum concentration of five tumor markers (TATI, SCC, CYFRA 21-1, TPA, and TPS) in patients without evidence of neoplasia
| Autor: | G, Tramonti, M, Ferdeghini, C, Donadio, M, Norpoth, C, Annichiarico, R, Bianchi, C, Bianchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Aged 80 and over Keratin-19 Male glomerular filtration rate renal failure Adolescent glomerular filtration rate low molecular weight proteins renal failure tumor markers Middle Aged low molecular weight proteins Antigens Neoplasm Trypsin Inhibitor Kazal Pancreatic tumor markers Creatinine Neoplasms Biomarkers Tumor Humans Keratins Female Renal Insufficiency Tissue Polypeptide Antigen Peptides Serpins Aged |
| Popis: | The aim of this study was to evaluate the relationship between renal function and the blood level of some tumor markers that are low molecular weight proteins, that is, tumor-associated trypsin inhibitor (TATI), squamous cells carcinoma antigen (SCC), cytokeratin 19 fragments (CYFRA 21-1), tissue polypeptide antigen (TPA), and M3-specific epitope of tissue polypeptide antigen (TPS). In 41 adult patients without evidence of neoplastic disease, glomerular filtration rate (GFR) and the blood levels of creatinine and of the tumor markers were determined. The decrease in GFR was accompanied by an increase in serum levels of TATI, SCC, CYFRA 21-1, and TPA. The serum level of tumor markers increased particularly when GFR fell below 40 ml/min. On the basis of these results, the renal function must be taken into account for the clinical evaluation of the studied tumor markers. |
| Databáze: | OpenAIRE |
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