The prognostic value of derived neutrophil to lymphocyte ratio in oesophageal cancer treated with definitive chemoradiotherapy
| Autor: | Cox, Samantha, Hurt, Christopher, Grenader, Tal, Mukherjee, Somnath, Bridgewater, John, Crosby, Thomas |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Prognostic biomarker Esophageal Neoplasms Neutrophils Oesophageal cancer Derived neutrophil–lymphocyte ratio (dNLR) Cetuximab Chemoradiotherapy Kaplan-Meier Estimate Adenocarcinoma Middle Aged Prognosis R1 Article Disease-Free Survival Definitive chemoradiotherapy (dCRT) Antineoplastic Combined Chemotherapy Protocols Carcinoma Squamous Cell Humans Female Esophageal Squamous Cell Carcinoma Lymphocytes Cisplatin Aged |
| Zdroj: | Radiotherapy and Oncology |
| ISSN: | 1879-0887 0167-8140 |
| Popis: | Background and purpose The derived neutrophil–lymphocyte ratio (dNLR) is a validated prognostic biomarker for cancer survival but has not been extensively studied in locally-advanced oesophageal cancer treated with definitive chemoradiotherapy (dCRT). We aimed to identify the prognostic value of dNLR in patients recruited to the SCOPE1 trial. Materials and methods 258 patients were randomised to receive dCRT ± cetuximab. Kaplan–Meier’s curves and both univariable and multivariable Cox regression models were calculated for overall survival (OS), progression free survival (PFS), local PFS inside the radiation volume (LPFSi), local PFS outside the radiation volume (LPFSo), and distant PFS (DPFS). Results An elevated pre-treatment dNLR ≥ 2 was significantly associated with decreased OS in univariable (HR 1.74 [95% CI 1.29–2.35], p |
| Databáze: | OpenAIRE |
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