Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly
| Autor: | Briet F, Achour L, bernard FLOURIE, Beaugerie L, Pellier P, Franchisseur C, Bornet F, Jc, Rambaud |
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| Přispěvatelé: | INSERM U290, Hôpital Saint-Lazare, Université Pierre et Marie Curie - Paris 6 (UPMC), Perron, Nicolas |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Diarrhea Male Cross-Over Studies Dose-Response Relationship Drug [CHIM.ORGA]Chemical Sciences/Organic chemistry digestive oral and skin physiology Oligosaccharides [CHIM.ORGA] Chemical Sciences/Organic chemistry Fructose Intolerance Breath Tests Double-Blind Method Dietary Carbohydrates Humans Female Hydrogen |
| Zdroj: | Europe PubMed Central European Journal of Clinical Nutrition European Journal of Clinical Nutrition, 1995, 49 ((7)), pp.501-7 |
| ISSN: | 0954-3007 1476-5640 |
| Popis: | International audience; OBJECTIVE: To evaluate in 14 healthy volunteers the gastrointestinal tolerance to an indigestible bulking sweetener containing fructo-oligosaccharides (FOS). DESIGN: In order to mimic their usual pattern of consumption, FOS were ingested throughout the day either occasionally (once a week, first period) or regularly (every day, second period). In the two patterns of consumption, daily sugar doses were increased until diarrhoea and/or a symptom graded 3 (i.e. severe) occurred, or when subjects did not want to ingest more candies. SETTING: Clinical Nutrition Unit, Hôpital Saint-Lazare, Paris. RESULTS: In both periods, the first symptom which occurred was excessive flatus (> 30 g FOS/day): borborygmi and bloating appeared at a higher level (> 40 g/day); lastly, abdominal cramps and diarrhoea occurred at a very much higher level (50 g/day). The volumes of hydrogen excreted in breath in response to the same load of FOS were not different between the two periods. CONCLUSIONS: Chronic consumption of FOS initiated cautiously with subsequent gradual increase did not improve tolerance, nor reduce breath excretion of hydrogen. |
| Databáze: | OpenAIRE |
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