| Autor: |
Padula, Francesco, Cignini, Pietro, Diana Giannarelli, Brizzi, Cristiana, Coco, Claudio, D Emidio, Laura, Giorgio, Elsa, Giorlandino, Maurizio, Mangiafico, Lucia, Mastrandrea, Marialuisa, Milite, Vincenzo, Mobili, Luisa, Nanni, Cinzia, Raffio, Raffaella, Taramanni, Cinzia, Vigna, Roberto, Mesoraca, Alvaro, Bizzoco, Domenico, Gabrielli, Ivan, Di Giacomo, Gianluca, Barone, Maria Antonietta, Cima, Antonella, Giorlandino, Francesca Romana, Emili, Sabrina, Cupellaro, Marina, Giorlandino, Claudio |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
ResearcherID |
| Popis: |
to assess the performance of a combined first-trimester screening for trisomy 21 in an unselected Italian population referred to a specialized private center for prenatal medicine.a retrospective validation of first-trimester screening algorithms [risk calculation based on maternal age and nuchal translucency (NT) alone, maternal age and serum parameters (free β-hCG and PAPP-A) alone and a combination of both] for fetal aneuploidies evaluated in an unselected Italian population at Artemisia Fetal-Maternal Medical Centre in Rome. All measurements were performed between 11(+0) and 13(+6) weeks of gestation, between April 2007 and December 2008.of 3,610 single fetuses included in the study, we had a complete follow-up on 2,984. Fourteen of 17 cases of trisomy 21 were detected when a cut-off of 1:300 was applied [detection rate (DR) 82.4%, 95% confidence interval (CI) 64.2-100; false-positive rate (FPR) 4.7%, 95% CI 3.9-5.4; false-negative rate (FNR) 17.6%, 95% CI 0-35.8%].in our study population the detection rate for trisomy 21, using the combined risk calculation based on maternal age, fetal NT, maternal PAPP-A and free β-hCG levels, was superior to the application of either parameter alone. The algorithm has been validated for first trimester screening in the Italian population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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