Efficacy and safety of peginterferon alfa-2b plus ribavirin for HCV-positive mixed cryoglobulinemia: a multicentre open-label study
| Autor: | Cesare Mazzaro, Monti, G., Saccardo, F., Zignego, A. L., Ferri, C., Vita, S., Gabrielli, A., Lenzi, M., Donada, C., Galli, M., Pietrogrande, M., Pozzato, G. |
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| Přispěvatelé: | Mazzaro, C, Monti, G, Saccardo, F, Zignego, Al, Ferri, C, De Vita, S, Gabrielli, A, Lenzi, M, Donada, C, Galli, M, Pietrogrande, M, Pozzato, Gabriele, Mazzaro C, Monti G, Saccardo F, Zignego AL, Ferri C, De Vita S, Gabrielli A, Lenzi M, Donada C, Galli M, Pietrogrande M, Pozzato G. |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male mixed cryoglobulinemia HCV Non-Hodgkin's lymphomas Vasculitis ribavirin Hepacivirus Interferon alpha-2 Antiviral Agents Polyethylene Glycols Liver Function Tests IFN Teraphy Ribavirin peginterferon Humans Aged Interferon-alpha virus diseases CRYOGLOBULINEMIA Hepatitis C Chronic Middle Aged Recombinant Proteins digestive system diseases Treatment Outcome Drug Therapy Combination Female |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | OBJECTIVES: The aim of the present study is to provide information on clinical outcome of the patients affected by HCV-positive mixed cryoglobulinemia (MC) treated with PEG-IFN and Ribavirin for 6 or 12 months according to the HCV genotype. METHODS: Eighty-six patients (42 women and 44 men) were enrolled in 8 Italian centres. All the patients had MC in the active phase of the disease. The patients received Peginterferon alfa-2b 1.5 mcg/kg/once a week (QW) and daily oral Ribavirin (800/1,000/1,200) according to their body weight for 48 weeks for genotype 1 and 4 and for 24 weeks for genotypes 2 and 3. RESULTS: In the 44 patients who underwent 12 months of therapy, 17 cases (39%) could be considered as 'non-responders' and 11 relapsed, therefore only 16 patients (36%) obtained a sustained virological response. In the 42 patients who underwent six months of therapy only 7 cases (17%) could be considered as 'non-responders' and 8 relapsed, therefore 27 patients (64%) obtained a sustained virological response. Purpura score dropped in both group (p |
| Databáze: | OpenAIRE |
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