Induction therapy with cyclosporine without cytolytic agents results in a low incidence of acute rejection without significant renal impairment in heart transplant patients
| Autor: | Jazzar, A., Stefano Fagiuoli, Sisson, S., Zuhdi, N., Cooper, D. K. C. |
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| Přispěvatelé: | Jazzar, A, Fagiuoli, S, Sisson, S, Zuhdi, N, Cooper, D |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Graft Rejection Male Adolescent Premedication Administration Oral Kidney Methylprednisolone Renal Dialysis Azathioprine Humans Glucocorticoids Aged Antilymphocyte Serum Incidence Middle Aged Heart transplantation cyclosporine Survival Rate Creatinine Acute Disease Injections Intravenous Cyclosporine Acute rejection Heart Transplantation Prednisone Female Immunosuppressive Agents Renal function Follow-Up Studies Muromonab-CD3 |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0902-0063 |
| Popis: | Since 1989, the immunosuppressive regimen used in all heart transplant patients at our center has consisted of (i) cyclosporine induction therapy (pretransplant p.o. 2-6 mg/kg depending on serum creatinine level, with immediate post-transplant i.v. therapy at 1-3 mg/h until p.o. therapy alone maintains a whole blood trough level of 300 ng/ml by RIA); (ii) azathioprine (2.5 mg/kg/d i.v./p.o.); (iii) methylprednisolone i.v. for 24 h and then prednisone p.o. at 1 mg/kg/d, tapering to 0.1 mg/kg/d at 1 yr. No prophylactic cytolytic agents (ALG, OKT3) were given. One hundred consecutive patients have been followed for periods of 4-56 months (mean 27 months). The incidence of acute rejection requiring increased therapy was 24%, with only 7% requiring i.v. steroids, 2 of whom (2%) also required ALG and/or OKT3, and with 17% requiring increased oral immunosuppression alone. Mean creatinine levels (mg/dl) were 1.3 pretransplant, 1.4 on d 7, 1.5 at 30 d, and 1.8 after 2 yr. Only 1 patient required temporary hemodialysis. Survival was 98% at 30 d, 94% at 1 yr, and 92% at 2 yr. We conclude that cyclosporine induction therapy with steroids and azathioprine without any cytolytic agent results in a low incidence of acute rejection without jeopardizing renal function. |
| Databáze: | OpenAIRE |
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