Characterisation of peripheral blood mononuclear cell microRNA in early onset psoriatic arthritis

Autor:	GIOVANNI CIANCIO, Ferracin M, Saccenti E, Bagnari V, Farina I, Furini F, Galuppi E, Zagatti B, Trotta F, Negrini M, Govoni M
Přispěvatelé:	Ciancio, Giovanni, Ferracin, Manuela, Saccenti, Elena, Bagnari, Valentina, Farina, Ilaria, Furini, Federica, Galuppi, Elisa, Zagatti, Barbara, Trotta, Francesco, Negrini, Massimo, Govoni, Marcello
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Adult Male psoriatic arthriti microRNA Gene Expression Profiling Arthritis Psoriatic Droplet digital PCR Micro-RNA MiR-21-5p Psoriasis Psoriatic arthritis Rheumatoid arthritis Middle Aged NO MicroRNAs Leukocytes Mononuclear Humans Female
Zdroj:	Scopus-Elsevier Europe PubMed Central
Popis:	OBJECTIVES: To evaluate the micro-RNA (miRNA) expression profile in patients with early psoriatic arthritis (PsA) in order to assess the role of miRNAs as potential PsA biomarkers. METHODS: The expression of 723 mature miRNAs in peripheral blood mononuclear cells of early PsA patients in comparison with early-rheumatoid arthritis (ERA) patients and healthy controls (HC) was evaluated using a miRNA microarray. All patients had active disease and were naïve from treatment. The results were validated for a specific miRNA (miR-21-5p) in the entire series of patients plus an additional group of early PsA, ERA and HC using droplet digital PCR. RESULTS: In PsA, microarray analysis revealed a distinct pattern of 19 (vs. HC) and 48 (vs. ERA) deregulated miRNAs (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::da720b2ad0c60a0428d85dde08aeb289 http://hdl.handle.net/11585/588067 Zobrazit plný text záznamu