Evaluation of S12363, a novel vinca alkaloid drug in the treatment of advanced malignant melanoma. A phase II study

Autor:	Stanley, A. J., Kaprielian, R., Retsas, S.
Rok vydání:	1993
Předmět:	Adult Male Dose-Response Relationship Drug Humans Female Middle Aged Antineoplastic Agents Phytogenic Melanoma Vinca Alkaloids Aged
Zdroj:	Europe PubMed Central Scopus-Elsevier
ISSN:	0250-7005
Popis:	We conducted a phase II study with the new vinca alkaloid derivative S12363 in ten patients with metastatic malignant melanoma. Six patients had been pre-treated with other cytotoxic agents and all had received Vindesine. Four patients had no prior systemic treatment before entry into the study. S12363 was well tolerated subjectively, the main toxicity being haematological. Despite encouraging in vitro observations, no objective responses to S12363 have been documented in these patients with the doses and schedule used in this study. S12363 appears to have no clinically useful activity in metastatic malignant melanoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d9cc85ff4cc03877f6fd733649b7e387 https://pubmed.ncbi.nlm.nih.gov/8476226 Zobrazit plný text záznamu