Treatment of human B-cell precursor leukemia in SCID mice using a combination of the investigational biotherapeutic agent B43-PAP with cytosine arabinoside
| Autor: | Messinger Y, Yanishevski Y, Vi, Avramis, Ek O, Lm, Chelstrom, Gunther R, Myers DE, Jd, Irvin, Evans W, Fatih M. Uckun |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Immunotoxins Cytarabine Antibodies Monoclonal Mice SCID Carmustine Specific Pathogen-Free Organisms Mice Treatment Outcome Doxorubicin Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Antineoplastic Combined Chemotherapy Protocols Ribosome Inactivating Proteins Type 1 Animals Humans Female N-Glycosyl Hydrolases Neoplasm Transplantation Etoposide Plant Proteins |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1078-0432 |
| Popis: | Combined immunochemotherapy regimens using the investigational biotherapeutic agent B43(anti-CD19)-poke-weed antiviral protein (PAP) immunotoxin may offer an effective treatment for refractory B-cell precursor leukemias. The purpose of the present study was to explore and identify effective combinations of B43-PAP with standard chemotherapeutic drugs, including the anthracyclin doxorubicin, the epipodophyllotoxin etoposide, the nitrosurea carmustine, and the antimetabolite cytosine arabinoside. Here, we report that the B43-PAP plus cytosine arabinoside combination has potent antileukemic activity against human B-cell precursor leukemia in SCID mice and leads to 100% long-term event-free survival from an otherwise invariably fatal leukemia. Surprisingly, none of the other treatment protocols tested, including combinations of B43-PAP with carmustine, doxorubicin, or etoposide, proved more effective than B43-PAP alone. |
| Databáze: | OpenAIRE |
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