Neural intersections of the phonological, visual magnocellular and motor/cerebellar systems in normal readers: Implications for imaging studies on dyslexia
Autor: | DANELLI, LAURA, BERLINGERI, MANUELA, Bottini, G, FERRI, FRANCESCA, Vacchi, L, Sberna, M, PAULESU, ERALDO |
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Přispěvatelé: | Danelli, L, Berlingeri, M, Bottini, G, Ferri, F, Vacchi, L, Sberna, M, Paulesu, E |
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Adult
Male genetic structures cerebellum reading developmental dyslexia occipitotemporal cortex fMRI Developmental dyslexia Models Neurological Motion Perception Models Psychological Motor Activity M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA behavioral disciplines and activities Dyslexia Young Adult Phonetics Cerebellum Humans Learning Research Articles Occipitotemporal cortex Motor Cortex Brain Magnetic Resonance Imaging Temporal Lobe Reading FMRI Positron-Emission Tomography Auditory Perception Speech Perception Visual Perception Female Occipital Lobe Nerve Net psychological phenomena and processes |
Zdroj: | Hum Brain Mapp |
Popis: | We used fMRI to explore the extent of the anatomical overlap of three neural systems that the literature on developmental dyslexia associates with reading: the auditory phonological, the visual magnocellular, and the motor/cerebellar systems. Twenty‐eight normal subjects performed four tasks during fMRI scans: word and pseudoword reading, auditory rhyming for letter names, visual motion perception, and a motor sequence learning task. We found that the left occipitotemporal cortex (OTC), which previous studies reported to be dysfunctional in dyslexia, can be fractionated into different functional areas: an anterior and lateral area that was activated by both reading and auditory rhyming tasks; a posterior area that was commonly activated by both the reading and the motion perception task and a medial/intermediate area, including the so‐called Visual Word Form Area, which was specifically activated by the reading task. These results show that the left OTC is an area of segregated convergence of different functional systems. We compared our results with the hypoactivation pattern reported for reading in a previous cross‐cultural PET study on 36 dyslexic subjects from three countries. The region of decreased activation in dyslexia overlapped with regions that are specific for reading and those activated during both the auditory rhyming task and the single word and pseudoword reading task described in the present fMRI study. No overlap was found with the activation patterns for the visual motion perception task or for the motor sequence learning task. These observations challenge current theories of dyslexia. Hum Brain Mapp 34:2669–2687, 2013. © 2012 Wiley Periodicals, Inc. |
Databáze: | OpenAIRE |
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