Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions

Autor:	Demarini, D. M., Stefano Landi, Tian, D., Hanley, N. M., Li, X., Hu, F., Roop, B. C., Mass, M. J., Keohavong, P., Gao, W., Olivier, M., Hainaut, P., Mumford, J. L.
Rok vydání:	2001
Předmět:	Coal Genes ras Lung Neoplasms Air Pollution Indoor Smoke Mutation Smoking Humans Female Environmental Exposure Middle Aged Polycyclic Aromatic Hydrocarbons Genes p53
Zdroj:	ResearcherID Europe PubMed Central Scopus-Elsevier
ISSN:	0008-5472
Popis:	We determined the TP53 and codon 12 KRAS mutations in lung tumors from 24 nonsmokers whose tumors were associated with exposure to smoky coal. Among any tumors studied previously, these showed the highest percentage of mutations that (a) were G --T transversions at either KRAS (86%) or TP53 (76%), (b) clustered at the G-rich codons 153-158 of TP53 (33%), and (c) had 100% of the guanines of the G --T transversions on the nontranscribed strand. This mutation spectrum is consistent with an exposure to polycyclic aromatic hydrocarbons, which are the primary component of the smoky coal emissions. These results show that mutations in the TP53 and KRAS genes can reflect a specific environmental exposure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d845c9dd483a7914d4165f12bcf6e9ec https://pubmed.ncbi.nlm.nih.gov/11559534 Zobrazit plný text záznamu