Evaluation of factors influencing 18 F-FET uptake in the brain

Autor: Verger, Antoine, Stegmayr, Carina, Galldiks, Norbert, van Der Gucht, Axel, Lohmann, Philipp, Stoffels, Gabriele, Shah, Nadim, Fink, Gereon, Eickhoff, Simon, Guedj, Eric, Langen, Karl-Josef
Přispěvatelé: Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Jülich Research Centre, Universität zu Köln, Lausanne University Hospital, Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), RWTH Aachen University, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Service de médecine nucléaire [Marseille], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine Nucléaire [CHRU Nancy], Universität zu Köln = University of Cologne, Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, 2018, 17, pp.491-497. ⟨10.1016/j.nicl.2017.11.005⟩
NeuroImage: Clinical, Vol 17, Iss, Pp 491-497 (2018)
NeuroImage: Clinical 17, 491–497 (2018). doi:10.1016/j.nicl.2017.11.005
NeuroImage. Clinical, vol. 17, pp. 491-497
NeuroImage : Clinical
Neuroimage-Clinical, 2018, 17, pp.491-497. ⟨10.1016/j.nicl.2017.11.005⟩
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2017.11.005⟩
Popis: PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18F-FET uptake in various brain areas, and thus affect quantification of 18F-FET uptake in brain tumours. Negative 18F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of 18F-FET uptake in the brain. In women, SUVmean of 18F-FET uptake in the brain was 23% higher than in men (p
Highlights • SUVmean of 18F-FET in the normal brain is influenced by gender. • SUVmean of 18F-FET in the normal brain is weekly influenced by BMI. • The influence of these factors on SUV of 18F-FET is similar in all brain areas.
Databáze: OpenAIRE
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