Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
| Autor: | Watts, EL, Appleby, PN, Albanes, D, Black, A, Chan, JM, Chen, C, Cirillo, PM, Cohn, BA, Cook, MB, Donovan, JL, Ferrucci, L, Garland, CF, Giles, GG, Goodman, PJ, Habel, LA, Haiman, CA, Holly, JMP, Hoover, RN, Kaaks, R, Knekt, P, Kolonel, LN, Kubo, T, Le Marchand, L, Luostarinen, T, Macinnis, RJ, Mäenpää, HO, Männistö, S, Metter, EJ, Milne, RL, Nomura, AMY, Oliver, SE, Parsons, JK, Peeters, PH, Platz, EA, Riboli, E, Ricceri, F, Rinaldi, S, Rissanen, H, Sawada, N, Schaefer, CA, Schenk, JM, Stanczyk, FZ, Stampfer, M, Stattin, P, Stenman, U-H, Tjønneland, A, Trichopoulou, A, Thompson, IM, Tsugane, S, Vatten, L, Whittemore, AS, Ziegler, RG, Allen, NE, Key, TJ, Travis, RC |
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| Přispěvatelé: | Department of Oncology, Clinicum, Department of Diagnostics and Therapeutics, HUS Comprehensive Cancer Center, Hu, C, Hu, Cheng |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging Physiology Datasets as Topic Biochemistry Adult Gonadal Steroid Hormones Humans Young Adult Anthropometry Behavior Social Class BINDING GLOBULIN CONCENTRATIONS Medicine and Health Sciences Testosterone Lipid Hormones Cancer Alcohol Consumption Estradiol Prostate Cancer Prostate Diseases Body Fluids Multidisciplinary Sciences Blood Oncology SERUM ANDROGENS Centre for Surgical Research Endokrinologi och diabetes Androgens Science & Technology - Other Topics Medicine Anatomy Research Article General Science & Technology PROSTATE-CANCER RISK Science DEHYDROEPIANDROSTERONE-SULFATE Urology 3122 Cancers UNITED-STATES STEROID-HORMONES Endocrinology and Diabetes MD Multidisciplinary Sex Hormones MIDDLE-AGED MEN Nutrition Science & Technology Biology and Life Sciences Cancers and Neoplasms Proteins Globulins Dehydroepiandrosterone Estrogen LIFE-STYLE FACTORS Hormones Diet Genitourinary Tract Tumors OLDER AFRICAN-AMERICAN PITUITARY-ADRENAL AXIS |
| Zdroj: | Watts, E L, Appleby, P N, Albanes, D, Black, A, Chan, J M, Chen, C, Cirillo, P M, Cohn, B A, Cook, M B, Donovan, J L, Ferrucci, L, Garland, C F, Giles, G G, Goodman, P J, Habel, L A, Haiman, C A, Holly, J M P, Hoover, R N, Kaaks, R, Knekt, P, Kolonel, L N, Kubo, T, Le Marchand, L, Luostarinen, T, MacInnis, R J, Mäenpää, H O, Männistö, S, Metter, E J, Milne, R L, Nomura, A M Y, Oliver, S E, Parsons, J K, Peeters, P H, Platz, E A, Riboli, E, Ricceri, F, Rinaldi, S, Rissanen, H, Sawada, N, Schaefer, C A, Schenk, J M, Stanczyk, F Z, Stampfer, M, Stattin, P, Stenman, U H, Tjønneland, A, Trichopoulou, A, Thompson, I M, Tsugane, S, Vatten, L, Whittemore, A S, Ziegler, R G, Allen, N E, Key, T J & Travis, R C 2017, ' Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men ', PLoS ONE, vol. 12, no. 12, e0187741 . https://doi.org/10.1371/journal.pone.0187741 Watts, EL; Appleby, PN; Albanese, D; Black, A; Chan, JM; Chen, C; et al.(2017). Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men. PLOS ONE, 12(12). doi: 10.1371/journal.pone.0187741. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5kc8x9ws PLoS ONE PLoS ONE [E], 12(12). Public Library of Science 12:e0187741 PLoS ONE, Vol 12, Iss 12, p e0187741 (2017) PloS one, vol 12, iss 12 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0187741 |
| Popis: | Introduction Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin. Methods Statistical analyses of individual participant data from 12,330 male controls aged 25–85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates. Results Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones. Conclusion Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
| Databáze: | OpenAIRE |
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