Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole
| Autor: | AKIF EVREN PARLAK, Celik S, Karatepe M, Turkoglu S, No, Alayunt, Sd, Dastan, Ulas M, Sandal S, Tekin S, Koparir M |
|---|---|
| Přispěvatelé: | [Parlak, A. E.] Firat Univ, Keban Vocat High Sch, TR-23740 Elazig, Turkey -- [Celik, S.] Usak Univ, Fac Dent, Usak, Turkey -- [Karatepe, M. -- Koparir, M.] Firat Univ, Dept Chem, Fac Sci, TR-23119 Elazig, Turkey -- [Turkoglu, S.] Firat Univ, Fac Hlth Sci, TR-23119 Elazig, Turkey -- [Alayunt, N. O.] Usak Univ, Banaz Vocat High Sch, TR-64200 Usak, Turkey -- [Dastan, S. D.] Cumhuriyet Univ, Fac Vet Med, Dept Biometr & Genet, TR-58140 Sivas, Turkey -- [Ulas, M.] Firat Univ, Dept Physiol, Fac Med, TR-23119 Elazig, Turkey -- [Sandal, S. -- Tekin, S.] Inonu Univ, Fac Med, Dept Physiol, TR-44000 Malatya, Turkey, Turkoglu, Semra -- 0000-0001-7682-0513, Parlak, Akif Evren -- 0000-0002-2579-9985 |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1165-158X |
| Popis: | WOS: 000386768700009 PubMed ID: 27453272 In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|