Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population
| Autor: | Saglar, Emel, Bozkturt, Ranu, Irkec, Murat |
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| Přispěvatelé: | Selçuk Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Popis: | WOS: 000337658400007 PubMed: 24967185 AIM: To investigate the association between apolipoprotein E (APOE) -219 T >G promoter polymorphism and primary open angle glaucoma(POAG). METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP). Genotype/ allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test. RESULTS: Although the frequency of APOE-219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear CID ratio was higher and progression was more compared to glaucoma patients with GT genotype. CONCLUSION: APOE-219 T >G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation. Scientific Research Fund of Hacettepe UniversityHacettepe University [0401601001] Supported by Scientific Research Fund of Hacettepe University (No.0401601001) |
| Databáze: | OpenAIRE |
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