Rab27a Contributes to the Processing of Inflammatory Pain in Mice
| Autor: | Gross, Tilman, Wack, Gesine, Syhr, Katharina M. J., Tolmachova, Tanya, Seabra, Miguel C., Geisslinger, Gerd, Niederberger, Ellen, Schmidtko, Achim, Kallenborn-Gerhardt, Wiebke |
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| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC), Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system mice Sensory Receptor Cells Mutation Missense Gene Expression Pain Article rab27 GTP-Binding Proteins Ganglia Spinal Animals lcsh:QH301-705.5 In Situ Hybridization Pain Measurement inflammatory pain Inflammation dorsal root ganglia spinal cord Immunohistochemistry Mice Mutant Strains Mice Inbred C57BL Disease Models Animal lcsh:Biology (General) Hyperalgesia Female Rab27a |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Cells Cells, Vol 9, Iss 1488, p 1488 (2020) Volume 9 Issue 6 |
| Popis: | Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dorsal horn of the spinal cord of mice. Rab27a mutant mice, which carry a single-nucleotide missense mutation of Rab27a leading to the expression of a nonfunctional protein, show reduced mechanical hyperalgesia and spontaneous pain behavior in inflammatory pain models, while their responses to acute noxious mechanical and thermal stimuli is not affected. Our study uncovers a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice. |
| Databáze: | OpenAIRE |
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