[Angiotensin II stimulates endothelin-1 release from human endothelial cells]
| Autor: | Ciafré SA, Di Gregorio F, Colasanti P, Di Benedetto A, Langella A, Di Ieso N, Liguori A, Colasanti R, Napoli C., D'ARMIENTO, FRANCESCO PAOLO |
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| Přispěvatelé: | Ciafré, Sa, D'Armiento, Fp, DI GREGORIO, F, Colasanti, P, DI BENEDETTO, A, Langella, A, DI IESO, N, Liguori, A, Colasanti, R, Napoli, Claudio, D'Armiento, FRANCESCO PAOLO, Di Gregorio, F, Di Benedetto, A, Di Ieso, N, Napoli, C. |
| Rok vydání: | 1993 |
| Předmět: |
Cultured
Receptors Angiotensin Time Factors Stimulation Chemical Cells Cultured Iodine Radioisotopes Endothelium Vascular Dose-Response Relationship Drug Angiotensin II Endothelins Humans Cells Settore BIO/13 Chemical Dose-Response Relationship Angiotensin Vascular Stimulation Receptors Endothelium Drug |
| Zdroj: | Recenti progressi in medicina. 84(4) |
| ISSN: | 0034-1193 |
| Popis: | Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide isolated from the culture supernatant of porcine aortic endothelial cells. This 21 amino-acid residue peptide has potent vasoconstrictive properties in vitro and in vivo. ET-1 action involves phosphatidylinositol turnover, calcium mobilization and protein kinase C activation. Endothelial cells have distinct receptors for different operating through hydrosoluble hormones. The aim of this study was to investigate on a possible role of angiotensin II (ANG II) to modulate the release ET-1 from human endothelial cells in vitro. These data revealed a time- and a dose-dependent increase of ET-1 production in response to ANG II. This mechanism may have important pathophysiological implications in vivo. In fact, a double-mechanism of secretion of ET-1 from endothelial cells could exist: one active in a physiological condition and an other in response to a vasoconstrictor stimuli (as well as ANG II). Furthermore, these results may suggest an additional favourable effect of ACE-inhibition in human hypertension therapy. |
| Databáze: | OpenAIRE |
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