Severity of respiratory failure at admission and in-hospital mortality in patients with COVID-19: a prospective observational multicentre study
| Autor: | Santus, Pierachille, Radovanovic, Dejan, Saderi, Laura, Marino, Pietro, Cogliati, Chiara, De Filippis, Giuseppe, Rizzi, Maurizio, Franceschi, Elisa, Pini, Stefano, Giuliani, Fabio, Del Medico, Marta, Nucera, Gabriella, Valenti, Vincenzo, Tursi, Francesco, Sotgiu, Giovanni |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Partial Pressure Pneumonia Viral Severe Acute Respiratory Syndrome Severity of Illness Index respiratory infections Betacoronavirus Risk Factors respiratory medicine (see thoracic medicine) Humans Hospital Mortality Prospective Studies Hypoxia Respiratory Medicine Lung Pandemics Aged Respiratory Distress Syndrome SARS-CoV-2 COVID-19 General Medicine Middle Aged Hospitals respiratory tract diseases virology Hospitalization Oxygen Intensive Care Units Italy respiratory physiology Female Blood Gas Analysis Coronavirus Infections Respiratory Insufficiency |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2020-043651 |
| Popis: | Objectives COVID-19 causes lung parenchymal and endothelial damage that lead to hypoxic acute respiratory failure (hARF). The influence of hARF severity on patients’ outcomes is still poorly understood. Design Observational, prospective, multicentre study. Setting Three academic hospitals in Milan (Italy) involving three respiratory high dependency units and three general wards. Participants Consecutive adult hospitalised patients with a virologically confirmed diagnosis of COVID-19. Patients aged 300 mm Hg). Primary and secondary outcome measures The primary outcome was the assessment of clinical characteristics and in-hospital mortality based on the severity of respiratory failure. Secondary outcomes were intubation rate and application of continuous positive airway pressure during hospital stay. Results 412 patients were enrolled (280 males, 68%). Median (IQR) age was 66 (55–76) years with a PaO2/FiO2 at admission of 262 (140–343) mm Hg. 50.2% had a cardiovascular disease. Prevalence of mild, moderate and severe hARF was 24.4%, 21.9% and 15.5%, respectively. In-hospital mortality proportionally increased with increasing impairment of gas exchange (p |
| Databáze: | OpenAIRE |
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