Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients
| Autor: | GOZUKARA, Mehmet Yavuz, Borekci, Abdurrezzak, Gur, Mustafa, Aksoy, Nurten, SEKER, Taner, KAYPAKLI, Onur, UCAR, Hakan, TURKOGLU, Caner, KOC, Mevlut, MAKCA, Ilyas, AKYOL, Selahattin, Selek, Sahbettin, CAYLI, Murat |
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| Přispěvatelé: | SELEK, ŞAHABETTİN |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Aryldialkylphosphatase GOZUKARA M. Y. Borekci A. Gur M. Aksoy N. SEKER T. KAYPAKLI O. UCAR H. TURKOGLU C. KOC M. MAKCA I. et al. -Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients- JOURNAL OF CLINICAL LABORATORY ANALYSIS cilt.29 ss.390-396 2015 Original Articles gamma-Glutamyltransferase Middle Aged Pulse Wave Analysis digestive system digestive system diseases Cohort Studies Vascular Stiffness Hypertension Humans Female Essential Hypertension Aorta |
| Popis: | BACKGROUND: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). METHODS: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single‐point method via the Mobil‐O‐Graph® ARCsolver algorithm. RESULTS: PWV, Aix, and high‐sensitive C‐reactive protein (hs‐CRP) values were higher and PON1 activity values were lower in GGT(high) group compared with GGT(low) group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = −0.343, P < 0.001) as well as hs‐CRP (β = 0.334, P < 0.001). CONCLUSION: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients. |
| Databáze: | OpenAIRE |
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