3D skin models in domestic animals

Autor: Souci, Laurent, Denesvre, Caroline
Přispěvatelé: Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Région Centre Val de Loire IA/FEDER grant (ANIMALT project), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Veterinary Research
Veterinary Research, BioMed Central, 2021, 52 (1), 15 p. ⟨10.1186/s13567-020-00888-5⟩
Veterinary Research, Vol 52, Iss 1, Pp 1-15 (2021)
ISSN: 0928-4249
1297-9716
DOI: 10.1186/s13567-020-00888-5⟩
Popis: International audience; The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest in various fields (for e.g. cell biology, medicine, toxicology, cosmetology, and pharmacology). In contrast to other organs, 3D models were mostly and directly elaborated in humans due to its architectural simplicity and easy accessibility. The development of these models benefited from the societal pressure to reduce animal experiments. In this review, we first describe human and mouse skin structure and the major differences with other mammals and birds. Next, we describe the different 3D human skin models and their main applications. Finally, we review the available models for domestic animals and discuss the current and potential applications.
Databáze: OpenAIRE
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