Growth differentiation factor 15 (GDF-15) in patients admitted for acute heart failure: results from the RELAX-AHF study

Autor:	Cotter, Gad, Voors, Adriaan A, Prescott, Margaret F, Felker, G Michael, Filippatos, Gerasimos, Greenberg, Barry H, Pang, Peter S, Ponikowski, Piotr, Milo, Olga, Hua, Tsushung A, Qian, Min, Severin, Thomas M, Teerlink, John R, Metra, Marco, Davison, Beth A
Přispěvatelé:	Cardiovascular Centre (CVC)
Rok vydání:	2015
Předmět:	Male Acute heart failure GDF-15 RELAX-AHF study Growth Differentiation Factor 15 Statistics as Topic BETA SUPERFAMILY MEMBER Severity of Illness Index Double-Blind Method Natriuretic Peptide Brain INJURY TROPONIN-T Humans Mortality Aged Aged 80 and over Heart Failure Relaxin Cardiovascular Agents Middle Aged Symptom Flare Up Peptide Fragments Recombinant Proteins Hospitalization Treatment Outcome embryonic structures Acute Disease TRIAL Female
Zdroj:	European Journal of Heart Failure, 17(11), 1133-1143. Wiley
ISSN:	1879-0844 1388-9842
Popis:	Background Growth differentiation factor 15 (GDF-15) was found to be upregulated in patients with chronic heart failure (HF) and associated with disease severity, however, data on patients with acute heart failure (AHF) is lacking. Methods and results Levels of GDF-15 were measured at pre-specified time-points (baseline and at days 2, 5, 14, and 60) in patients enrolled in the placebo-controlled RELAXin in Acute Heart Failure (RELAX-AHF) study, which examined the effect of serelaxin in 1161 patients with AHF, systolic blood pressure >125 mmHg, and mild to moderate renal impairment. Neither baseline nor changes in GDF-15 were associated with the degree of dyspnoea or dyspnoea relief. After adjustment for baseline characteristics, baseline GDF-15 was not associated with the composite endpoint of heart failure or renal failure (HF/RF) readmission at 60 days/cardiovascular (CV) death or CV death at 180 days. In contrast, larger increases in GDF-15 levels at days 2 and 14 were associated with a greater risk of 60-day HF/RF rehospitalizations/CV death and CV death at 180 days. Serelaxin treatment was associated with significantly larger decreases of GDF-15 at days 2 and 5 than placebo. Conclusions In AHF patients enrolled in the RELAX-AHF study, increases in GDF-15 levels, but not baseline measurements, were associated with a greater likelihood of adverse outcomes. Serelaxin administration was associated with greater decreases in GDF-15 compared with placebo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2281d149fbf76f0b04e4a5f03e79bdf https://pubmed.ncbi.nlm.nih.gov/26333529 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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