Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia

Autor: Mahtab, Sharifi, Elizabeth, Higginson, Sven, Bos, Angela, Gallivan, Darren, Harvey, Ka Wah, Li, Amali, Abeysekera, Angela, Haddon, Helen, Ashby, Kate E, Shipman, Jackie A, Cooper, Marta, Futema, Jeanine E, Roeters van Lennep, Eric J G, Sijbrands, Mourad, Labib, Devaki, Nair, Steve E, Humphries
Přispěvatelé: Internal Medicine
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Atherosclerosis
Atherosclerosis, 263, 405-411. Elsevier Ireland Ltd
ISSN: 1879-1484
0021-9150
Popis: Background and aims Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes causing FH and are most likely to have a polygenic cause for their raised LDL-C. We assessed the degree of preclinical atherosclerosis in treated patients with monogenic FH versus polygenic hypercholesterolemia. Methods FH mutation testing and genotypes of six LDL-C-associated single nucleotide polymorphisms (SNPs) were determined using routine methods. Those with a detected mutation (monogenic) and mutation-negative patients with LDL-C SNP score in the top two quartiles (polygenic) were recruited. Carotid intima media thickness (IMT) was measured by B-mode ultrasound and the coronary artery calcium (CAC) score was performed in three lipid clinics in the UK and the Netherlands. Results 86 patients (56 monogenic FH, 30 polygenic) with carotid IMT measurement, and 166 patients (124 monogenic, 42 polygenic) with CAC score measurement were examined. After adjustment for age and gender, the mean of all the carotid IMT measurements and CAC scores were significantly greater in the monogenic than the polygenic patients [carotid IMT mean (95% CI): 0.74 mm (0.7–0.79) vs. 0.66 mm (0.61–0.72), p = 0.038 and CAC score mean (95%): 24.5 (14.4–41.8) vs. 2.65 (0.94–7.44), p = 0.0004]. Conclusions In patients with a diagnosis of FH, those with a monogenic cause have a higher severity of carotid and coronary preclinical atherosclerosis than those with a polygenic aetiology.
Highlights • Patients with clinical FH but no detectable mutation are likely to have a polygenic cause for their raised LDL-C. • Preclinical atherosclerosis was measured in both groups, matched for lipid levels. • Carotid Intima Media Thickness was greater in monogenic vs polygenic patients. • Coronary artery calcification score was greater in monogenic vs polygenic patients. • Monogenic FH patients have greater preclinical atherosclerosis than those with a polygenic aetiology.
Databáze: OpenAIRE
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