Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions
| Autor: | Wernicke, Anna-Katharina, Churin, Yuri, Sheridan, Diana, Windhorst, Anita, Tschuschner, Annette, Gattenlöhner, Stefan, Roderfeld, Martin, Roeb, Elke |
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| Přispěvatelé: | Department of Gastroenterology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Aged
80 and over Male MMP Biopsy Middle Aged Immunohistochemistry Medical sciences Medicine neoplasia colon cancer Matrix Metalloproteinase 13 Humans adenoma Female ddc:610 Neoplasm Grading Colorectal Neoplasms Precancerous Conditions Biomarkers Research Paper Aged Neoplasm Staging immunoreactive scoring |
| Zdroj: | Oncotarget 7(45):73552-73557 doi: 10.18632/oncotarget.12429 Oncotarget |
| Popis: | An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout. The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions. |
| Databáze: | OpenAIRE |
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