Endothelial Retargeting of AAV9 In Vivo

Autor: Bozoglu, Tarik, Lee, Seungmin, Ziegler, Tilman, Jurisch, Victoria, Maas, Sanne, Baehr, Andrea, Hinkel, Rabea, Hoenig, Amelie, Hariharan, Anjana, Kim, Christina Inyeop, Decker, Simon, Sami, Haider, Koppara, Tobias, Oellinger, Ruppert, Müller, Oliver J., Frank, Derk, Megens, Remco, Nelson, Peter, Weber, Christian, Schnieke, Angelika, Sperandio, Markus, Santamaria, Gianluca, Rad, Roland, Moretti, Alessandra, Laugwitz, Karl‐Ludwig, Soehnlein, Oliver, Ogris, Manfred, Kupatt, Christian
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Popis: Adeno-associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV-transduction. AAVs are retargeted here toward endothelial cells by coating with second-generation polyamidoamine dendrimers (G2) linked to endothelial-affine peptides (CNN). G2
Databáze: OpenAIRE