Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo
| Autor: | Arlt, Olga, Schwiebs, Anja, Japtok, Lukasz, Rüger, Katja, Katzy, Elisabeth, Kleuser, Burkhard, Radeke, Heinfried Hermann |
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| Rok vydání: | 2014 |
| Předmět: |
Inflammation
Sphingosine-1-phosphate lcsh:QP1-981 Toll-Like Receptors Fingolimod Dendritic Cells Adaptive Immunity Skin Diseases lcsh:Physiology Immunity Innate lcsh:Biochemistry IL-12 Sphingosine Animals Cytokines Humans lipids (amino acids peptides and proteins) lcsh:QD415-436 ddc:610 Antigens Lysophospholipids Transcriptome |
| Zdroj: | Cellular Physiology and Biochemistry, Vol 34, Iss 1, Pp 27-44 (2014) |
| ISSN: | 1421-9778 |
| Popis: | Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen-presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well-synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DC homeostasis and the role of S1P and S1P metabolism in inflammatory diseases. |
| Databáze: | OpenAIRE |
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