Motor and sensory re-innervation of the lung and heart after re-anastomosis of the cervical vagus nerve in rats
| Autor: | Bregeon, Fabienne, Alliez, Jean Roch, Héry, Géraldine, Marqueste, Tanguy, Ravailhe, Sylvie, Jammes, Yves |
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| Přispěvatelé: | Laboratoire de Physiopathologie Respiratoire (UPRES EA 2201), Université de la Méditerranée - Aix-Marseille 2-Institut Fédératif de Recherches Jean ROCHE (IFR 11)-Faculté de Médecine Nord, Laboratoire des Déterminants Physiologiques de l'Activité Physique, Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Nerve Regeneration
Time Factors MESH: Rats Diaphragm Neural Conduction Action Potentials MESH: Rats Sprague-Dawley Vagotomy Rats Sprague-Dawley MESH: Electromyography Electrocardiography MESH: Neural Conduction Heart Rate MESH: Vagus Nerve Integrative Animals MESH: Animals MESH: Lung Neurons Afferent MESH: Vagotomy MESH: Heart Rate Lung MESH: Action Potentials Motor Neurons MESH: Respiration Electromyography Respiration MESH: Neurons Afferent digestive oral and skin physiology MESH: Time Factors MESH: Electric Stimulation Heart Neural Inhibition Vagus Nerve MESH: Neural Inhibition Electric Stimulation Nerve Regeneration Rats MESH: Electrocardiography MESH: Heart MESH: Diaphragm Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Female MESH: Motor Neurons |
| Zdroj: | The Journal of Physiology The Journal of Physiology, Wiley, 2007, 581 (Pt 3), pp.1333-40. ⟨10.1113/jphysiol.2007.131326⟩ The Journal of Physiology, 2007, 581 (Pt 3), pp.1333-40. ⟨10.1113/jphysiol.2007.131326⟩ |
| ISSN: | 0022-3751 1469-7793 |
| DOI: | 10.1113/jphysiol.2007.131326⟩ |
| Popis: | There is no study in the literature dealing with re-innervation of the cardiopulmonary vagus nerve after its transection followed by re-anastomosis. In the present study, we explored the bronchomotor, heart rate and respiratory responses in rats at 2, 3 and 6 months after re-anastomosis of one cervical vagus trunk. The conduction velocity of A, B and C waves was calculated in the compound vagal action potential. We searched for afferent vagal activities in phase with pulmonary inflation to assess the persistence of pulmonary stretch receptor (PSR) discharge in re-innervated lungs. In each animal, data from the stimulation or recording of one re-anastomosed vagus nerve were compared with those obtained in the contra-lateral intact one. Two and three months after surgery, the conduction velocities of A and B waves decreased, but recovery of conduction velocity was complete at 6 months. By contrast, the conduction velocity of the C wave did not change until 6 months, when it was doubled. The PSR activity was present in 50% of re-anastomosed vagus nerves at 2 and 3 months and in 75% at 6 months. Respiratory inhibition evoked by vagal stimulation was significantly weaker from the re-anastomosed than intact nerve at 2 but not 3 months. Vagal stimulation did not elicit cardiac slowing or bronchoconstriction 6 months after re-anastomosis. Our study demonstrates the capacity of pulmonary vagal sensory neurones to regenerate after axotomy followed by re-anastomosis, and the failure of the vagal efferents to re-innervate both the lungs and heart. |
| Databáze: | OpenAIRE |
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