Concomitant primary hemochromatosis and beta-thalassemia trait: iron depletion by erythrocytapheresis and desferrioxamine
| Autor: | Cesana, M, Mandelli, C, Bianchi, Pa, Conte, D., TIRIBELLI, CLAUDIO |
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| Přispěvatelé: | Cesana, M, Mandelli, C, Tiribelli, Claudio, Bianchi, Pa, Conte, D. |
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Deferoxamine/therapeutic use Adult Blood Component Removal* Deferoxamine/therapeutic use* Erythrocytes* Female Ferritins/blood Hemochromatosis/complications Hemochromatosis/pathology Hemochromatosis/therapy* Humans Liver/pathology Male Middle Aged Thalassemia/complications* Transferrin/metabolism Erythrocytes Ferritins/blood Hemochromatosis/therapy Hemochromatosis/pathology Thalassemia/complications Transferrin Transferrin/metabolism Deferoxamine Middle Aged Hemochromatosis/complications Liver Ferritins Blood Component Removal Humans Thalassemia Female Hemochromatosis Liver/pathology |
| Zdroj: | The American journal of gastroenterology. 84(2) |
| ISSN: | 0002-9270 |
| Popis: | Six men and one woman with mild anemia due to beta-thalassemia trait and major iron overload attributable to concomitant primary hemochromatosis were treated by erythrocytapheresis to remove iron, combined with subcutaneous desferrioxamine in the four cases with greater iron load. Depletion was achieved by iron removal of 4.5-15.1 g after 9-24 months' treatment. No side effects were observed, suggesting that such a regimen is effective and safe in this particular subgroup of hemochromatotics. |
| Databáze: | OpenAIRE |
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