[Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue]
| Autor: | Villanueva, Cristian, Dufresne, Armelle, Pivot, Xavier, Viel, Erika |
|---|---|
| Přispěvatelé: | Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Saas, Philippe |
| Jazyk: | francouzština |
| Rok vydání: | 2008 |
| Předmět: |
Male
MESH: Drug Hypersensitivity [SDV.IMM] Life Sciences [q-bio]/Immunology Maximum Tolerated Dose Paclitaxel MESH: Taxoids Breast Neoplasms Drug Hypersensitivity Clinical Trials Phase II as Topic Bone Marrow Neoplasms MESH: Tubulin Modulators Animals Humans MESH: Animals MESH: Neoplasms MESH: Epothilones MESH: Paclitaxel MESH: Humans Clinical Trials Phase I as Topic Peripheral Nervous System Diseases MESH: Maximum Tolerated Dose Tubulin Modulators MESH: Male MESH: Drug Resistance Neoplasm MESH: Clinical Trials Phase I as Topic Drug Resistance Neoplasm Epothilones [SDV.IMM]Life Sciences [q-bio]/Immunology Female Taxoids MESH: Bone Marrow MESH: Peripheral Nervous System Diseases MESH: Clinical Trials Phase II as Topic MESH: Female MESH: Breast Neoplasms |
| Zdroj: | Bulletin du Cancer Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (2), pp.197-204. ⟨10.1684/bdc.2008.0577⟩ |
| ISSN: | 0007-4551 1769-6917 |
| DOI: | 10.1684/bdc.2008.0577⟩ |
| Popis: | International audience; The epothilones are a new class of non-taxane tubulin polymerization agents obtained by natural fermentation of the myxobacteria Sorangium cellulosum. The cytotoxic activities of the epothilones, like those of the taxanes, have been linked to stabilization of microtubules, but they also have important differences. Among the epothilone family, ixabepilone (BMS247550) is a semisynthetic derivative of the natural product epothilone B. Ixabepilone was evaluated in vivo in a panel of human and rodent tumour models, the majority of which were chosen because of their known, well-characterized resistance to paclitaxel, and seems able to overcome the over-expression of multidrug resistance and to be unaffected by mutations in the beta tubulin gene. The interest of ixabepilone was clinically confirmed in clinical studies of phase II which demonstrated a strong activity at the patients with metastatic breast cancer resistant to taxanes and in patients suffering of other types of chemoresistant tumors. |
| Databáze: | OpenAIRE |
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