SARS-CoV-2 infection in cystic fibrosis: A multicentre prospective study with a control group, Italy, February-July 2020
| Autor: | Colombo, C., Alicandro, G., Dacco, V., Gagliano, V., Morlacchi, L. C., Casciaro, R., Pisi, G., Francalanci, M., Badolato, R., Bignamini, E., Messore, B., Lucanto, M. C., Leonetti, G., Maschio, M., Cipolli, M. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
Male Viral Diseases Pulmonology Cystic Fibrosis Coronaviruses Epidemiology Medical Conditions Antibiotics Prospective Studies Pathology and laboratory medicine Virus Testing Antimicrobials Drugs Disease Management Medical microbiology Hospitalization Chemistry Infectious Diseases Italy Genetic Diseases Viruses Physical Sciences Female SARS CoV 2 Pathogens Research Article Chemical Elements Adult SARS coronavirus Microbiology Respiratory Disorders Young Adult Autosomal Recessive Diseases Diagnostic Medicine Microbial Control Humans Pandemics Medicine and health sciences Clinical Genetics Pharmacology Biology and life sciences SARS-CoV-2 Organisms Viral pathogens COVID-19 Covid 19 Fibrosis Microbial pathogens Oxygen Respiratory Infections Developmental Biology |
| Zdroj: | PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Objective To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF). Methods We carried out a prospective multicentre cohort study based on 32 CF centres and 6597 patients. Centres were contacted to collect baseline and follow-up data of patients who reported symptoms suggestive of COVID-19 or who had contact with a positive/suspected case between the end of February and July 2020. Symptoms and clinical course of the infection were compared between patients who tested positive by molecular testing (cases) and those who tested negative (controls). Results Thirty patients were reported from the centres, 16 of them tested positive and 14 tested negative. No differences in symptoms and outcome of the disease were observed between groups. Fever, cough, asthenia and dyspnea were the most frequently reported symptoms. Eight cases (50%) were hospitalized but none required ICU admission. Two adults with a history of lung transplant required non-invasive ventilation, none required ICU admission and all patients fully recovered without short-term sequelae. Conclusions The course of SARS-CoV-2 in our patients was relatively favorable. However, COVID-19 should not be considered a mild disease in CF patients, particularly for those with severely impaired respiratory function and organ transplant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|