Protein supplementation during an energy-restricted diet induces visceral fat loss and gut microbiota amino acid metabolism activation: a randomized trial
| Autor: | Bel Lassen, Pierre, Belda, Eugeni, Prifti, Edi, Dao, Maria Carlota, Specque, Florian, Henegar, Corneliu, Rinaldi, Laure, Wang, Xuedan, Kennedy, Sean, Zucker, Jean-Daniel, Calame, Wim, Lamarche, Benoît, Claus, Sandrine, Clément, Karine |
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| Přispěvatelé: | Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de nutrition [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Integrative Phenomics [Paris], Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO), Institut de Recherche pour le Développement (IRD [France-Nord])-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Université de Yaoundé I-Sorbonne Université (SU), YSOPIA Bioscience [Bordeaux], University of Reading (UOR), Département de Biologie Computationnelle - Department of Computational Biology, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Laval [Québec] (ULaval), This study was supported by several sources: YSOPIA Bioscience sponsored the clinical investigation study. Funding for the detailed microbiota study (sequencing and analysis) were obtained from the French National Agency of Research ANR ('Investissement d’Avenir' FORCE, the Metagenopolis Grant ANR-11-DPBS-0001 and ICAN, reference ANR-10-IAHU-05) as well as European Union, FP7-sponsored program METACARDIS (HEALTH-F4-2012-30531). Grants were also obtained by JPI (A healthy diet for a healthy life, 2017-01996_3) and the Leducq Foundation (Transatlantic Networks of Excellence Award 17CVD01)., ANR-11-DPBS-0001,MGP,MetaGenoPolis(2011), ANR-10-IAHU-0005,ICAN,Institut de Cardiologie-Métabolisme-Nutrition(2010), European Project: 305312,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,METACARDIS(2012), Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Yaoundé I-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord]), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL-SU, Gestionnaire, Démonstrateurs - MetaGenoPolis - - MGP2011 - ANR-11-DPBS-0001 - DPBS - VALID, Instituts Hospitalo-Universitaires - Institut de Cardiologie-Métabolisme-Nutrition - - ICAN2010 - ANR-10-IAHU-0005 - IAHU - VALID, Metagenomics in Cardiometabolic Diseases - METACARDIS - - EC:FP7:HEALTH2012-11-01 - 2017-10-31 - 305312 - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Adult Male Microbiota Science [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Intra-Abdominal Fat Metabolic syndrome Article Gastrointestinal Microbiome [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Double-Blind Method Weight Loss Randomized controlled trials Humans Medicine Metagenomics Obesity Microbiome [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Caloric Restriction |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.15620. ⟨10.1038/s41598-021-94916-9⟩ Scientific Reports, 2021, 11 (1), pp.15620. ⟨10.1038/s41598-021-94916-9⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-94916-9⟩ |
| Popis: | Interactions between diet and gut microbiota are critical regulators of energy metabolism. The effects of fibre intake have been deeply studied but little is known about the impact of proteins. Here, we investigated the effects of high protein supplementation (Investigational Product, IP) in a double blind, randomised placebo-controled intervention study (NCT01755104) where 107 participants received the IP or an isocaloric normoproteic comparator (CP) alongside a mild caloric restriction. Gut microbiota profiles were explored in a patient subset (n = 53) using shotgun metagenomic sequencing. Visceral fat decreased in both groups (IP group: − 20.8 ± 23.2 cm2; CP group: − 14.5 ± 24.3 cm2) with a greater reduction (p |
| Databáze: | OpenAIRE |
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