[Effects of dietary fat level on the xenobiotic metabolism enzymes activity and antioxidant enzymes in rats]
| Autor: | Lv, Kravchenko, Ilya Aksenov, Nv, Trusov, Gv, Guseva, Li, Avren Eva |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Glutathione Peroxidase Aryldialkylphosphatase Catalase Dietary Fats Antioxidants Rats Glutathione Reductase Liver Cytochrome P-450 CYP1A2 Malondialdehyde Cytochrome P-450 CYP2B1 Cytochrome P-450 CYP1A1 Microsomes Liver Animals Cytochrome P-450 CYP3A Plant Oils Sunflower Oil Aryl Hydrocarbon Hydroxylases Glucuronosyltransferase Rats Wistar Diet Fat-Restricted Heme Oxygenase-1 Glutathione Transferase |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0042-8833 |
| Popis: | Male Wistar rats received fat-free diet or diets containing 5, 10 and 30% of fat (sunflower oil + lard, 1:1) for 4 weeks. The direct relationship between dietary fat level and ethoxyresorufin O-dealkylase activity of CYP1A1, methoxyresorufin O-dealkylase activity of CYP1A2, pentoxyresorufin O-dealkylase activity of CYP2B1 and testosterone 6beta-hydroxylase activity of CYP3A was found. Activities of key enzymes of phase II xenobiotic metabolism (total activity of glutathione transferase, activity of UDP-glucuronosyle transferase) and antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, paraoxonase-1 and heme oxygenase-1) also increased with higher dietary fat level. |
| Databáze: | OpenAIRE |
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