Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals
| Autor: | Gs, Stein, Jl, Stein, Jb, Lian, Aj, Wijnen, Montecino M, Amjad Javed, Sk, Zaidi, Young D, Jy, Choi, Pockwinse S |
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| Rok vydání: | 2004 |
| Předmět: |
Cell Nucleus
Transcription Genetic Active Transport Cell Nucleus Core Binding Factor alpha Subunits Neoplasm Proteins DNA-Binding Proteins Gene Expression Regulation Neoplastic Core Binding Factor Alpha 3 Subunit Gene Expression Regulation Neoplasms Animals Nuclear Matrix Signal Transduction Transcription Factors |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1121-760X |
| Popis: | Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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