[Non-fatal disseminated mucormycosis in a solid organ transplant]
| Autor: | Minet, Clémence, Bonadona, Agnès, Tabah, Alexis, Karkas, Alexandre, Mescam, L., Schwebel, Carole, Hamidfar, Rebecca, Pison, Christophe, Saint-Raymond, Christel, Faure, Odile, Salameire, Dimitri, Timsit, Jean-François |
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| Přispěvatelé: | Unité de pneumologie, CHU Grenoble, Unité de Réanimation médicale, Unité d'Oto-rhinolaryngologie, Département d'anatomie et cythologie pathologique, CHU Grenoble-Hôpital Michallon, Clinique de réanimation médicale, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Unité de Parasitologie-mycologie, Laboratoire de parasitologie et mycologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, INSERM U823, équipe 11 (Epidémiologie des cancers et des affections graves), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Unité de Réanimation médicale, Vesin, Aurélien |
| Jazyk: | francouzština |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Antifungal Agents Lung Diseases Fungal Opportunistic Infections Triazoles Combined Modality Therapy Thyroid Diseases Debridement [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Amphotericin B Humans Mucormycosis Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Absidia Lung Transplantation |
| Zdroj: | Revue des Maladies Respiratoires Revue des Maladies Respiratoires, Elsevier Masson, 2009, 26 (9), pp.998-1002 |
| ISSN: | 0761-8425 1776-2588 |
| Popis: | International audience; BACKGROUND: Mucormycosis is a rare fungal infection occurring most frequently in immunocompromised patients. The pathogens are filamentous fungi, order of Mucorales. Disseminated mucormycosis is a severe, life treating disease. Early diagnosis is a major determinant for prognosis, however, it remains difficult. The management consists in an early antifungal therapy using lipid formulation of amphotericin B associated with an extensive surgical debridement. Despite this therapeutic of choice, the mortality of disseminated mucormycosis remains high. OBSERVATION: We report the case of disseminated mucormycosis in a 25 years old woman 9 months after a pulmonary transplantation. The clinical presentation included pulmonary and thyroid localization and the pathogen was Absidia corymbifera. The patient survived thanks to a large surgical debridement, and an early antifungal bitherapy by lipid formulation of amphotericin B and posaconazole. CONCLUSION: The re-emergence and the high mortality of mucormycosis in solid organ transplant receiver show the necessity to find new therapeutic approaches. Posaconazole associated with liposomal amphotericin B could be an interesting option to treat disseminated mucormycosis and improve their outcome. |
| Databáze: | OpenAIRE |
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