Deleterious Effects of Cold Air Inhalation on Coronary Physiological Indices in Patients With Obstructive Coronary Artery Disease
| Autor: | Williams, RP, Asrress, KN, Lumley, M, Arri, S, Patterson, T, Ellis, H, Manou‐Stathopoulou, V, Macfarlane, C, Chandran, S, Moschonas, K, Oakeshott, P, Lockie, T, Chiribiri, A, Clapp, B, Perera, D, Plein, S, Marber, MS, Redwood, SR |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cardiac Catheterization Physiology Magnetic Resonance Imaging Cine Coronary Angiography Electrocardiography Oxygen Consumption Exercise Physiology Ischemia Coronary Circulation Humans wave intensity analysis coronary Original Research Retrospective Studies coronary microvascular resistance Hemodynamics Coronary Stenosis Middle Aged cold Coronary Vessels coronary flow Cold Temperature Exercise Test Female Blood Flow Velocity Follow-Up Studies |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background: Cold air inhalation during exercise increases cardiac mortality, but the pathophysiology is unclear. During cold and exercise, dual‐sensor intracoronary wires measured coronary microvascular resistance (MVR) and blood flow velocity (CBF), and cardiac magnetic resonance measured subendocardial perfusion.\ud \ud \ud \ud Methods and Results: Forty‐two patients (62±9 years) undergoing cardiac catheterization, 32 with obstructive coronary stenoses and 10 without, performed either (1) 5 minutes of cold air inhalation (5°F) or (2) two 5‐minute supine‐cycling periods: 1 at room temperature and 1 during cold air inhalation (5°F) (randomized order). We compared rest and peak stress MVR, CBF, and subendocardial perfusion measurements. In patients with unobstructed coronary arteries (n=10), cold air inhalation at rest decreased MVR by 6% (P=0.41), increasing CBF by 20% (P |
| Databáze: | OpenAIRE |
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