Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature
| Autor: | Lajolo, C, CAMPISI, Giuseppina, Deli, G, Littarru, C, GUIGLIA, Rosario, Giuliani, M. |
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| Přispěvatelé: | Lajolo, C, Campisi, G, Deli, G, Littarru, C, Guiglia, R, Giuliani, M |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Palate
Langerhans's cell histiocytosis S100 Proteins Antineoplastic Agents Antineoplastic Agents Phytogenic langerhans’s cell histiocytosis old subjects langerin oral immunohistochemistry Antigens CD1 Diagnosis Differential Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE Histiocytosis Langerhans-Cell Mannose-Binding Lectins Antigens CD Erythema Cladribine Humans Female Lectins C-Type Mandibular Diseases Radiotherapy Adjuvant Vulvar Diseases Mouth Diseases Periodontal Diseases Aged Etoposide |
| Popis: | Background: Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children; LCH onset is rare in adults; immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial. Objective: To describe two new cases of adult onset oral LCH. Case reports: Case 1: a 71-year-old woman, complaining of diffuse oral pain, presented with erythematous mucosal lesions; the panoramic radiograph and CT scan showed multiple mandible radiolucent areas. Immunohistochemical assay for S-100, CD1a and langerin test was essential in reaching the correct diagnosis. Case 2: a 77-year-old female patient presented with a non-painful, non-bleeding, slightly elevated erythematous palatal lesion of 6 months duration, together with a genital vulvar lesion of uncertain nature. The pathology confirmed the diagnosis of LCH. Many therapies (etoposid, radiotherapy) could induce only a clinical partial remission; Cladribine induced a complete recovery. Conclusion: The first case was difficult to diagnose: the clinical presentation and course of the disease (LCH) in the elderly are multiple and unpredictable. An immunohistochemistry study is often essential to obtain the correct diagnosis. The second case required several therapeutic interventions: even though some cases regress spontaneously, others require systemic chemotherapy. |
| Databáze: | OpenAIRE |
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