Brain network dysregulation, emotion, and complaints after mild traumatic brain injury
| Autor: | van der Horn, Harm J., Liemburg, Edith J., Scheenen, Myrthe E., de Koning, Myrthe E., Marsman, Jan-Bernard C., Spikman, Jacoba M., van der Naalt, Joukje |
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| Přispěvatelé: | Clinical Neuropsychology, Perceptual and Cognitive Neuroscience (PCN), Molecular Neuroscience and Ageing Research (MOLAR), Movement Disorder (MD), Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male emotion regulation SEX-DIFFERENCES Adolescent Emotions POSTCONCUSSIVE SYMPTOMS HOSPITAL ANXIETY CONCUSSION Young Adult post-traumatic complaints CONNECTIVITY mild traumatic brain injury Humans Prospective Studies Research Articles Brain Concussion fMRI HEAD-INJURY Brain Middle Aged brain networks Magnetic Resonance Imaging DEPRESSION SCALE DEFAULT-MODE TASK Female RESTING-STATE Nerve Net Follow-Up Studies |
| Zdroj: | Hum Brain Mapp Human brain mapping, 37(4), 1645-1654. Wiley |
| ISSN: | 1065-9471 |
| Popis: | OBJECTIVES: To assess the role of brain networks in emotion regulation and post‐traumatic complaints in the sub‐acute phase after non‐complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty‐four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group‐matched for age, sex, education, and handedness) were included. Resting‐state fMRI was performed at four weeks post‐injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS‐A) and depression (HADS‐D). PRINCIPAL OBSERVATIONS: Regarding within‐network functional connectivity, none of the selected brain networks were different between groups. Regarding between‐network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS‐D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS‐D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS‐A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions. Hum Brain Mapp 37:1645‐1654, 2016. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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