Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons

Autor:	Gholam Hossein Meftahi, Ghotbedin, Z., Eslamizade, M. J., Hosseinmardi, N., Janahmadi, M.
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Neurons Whole Cell Patch Clamp lcsh:R Neurosciences food and beverages lcsh:Medicine Electrophysiology Cellular and Molecular Biology Resveratrol Original Article lcsh:Q Action Potential skin and connective tissue diseases lcsh:Science
Zdroj:	Cell Journal, Vol 17, Iss 3, Pp 532-539 (2015) Cell Journal (Yakhteh) Scopus-Elsevier
ISSN:	2228-5814 2228-5806
Popis:	Objective Resveratrol, a phytoalexin, has a wide range of desirable biological actions. Despite a growing body of evidence indicating that resveratrol induces changes in neu- ronal function, little effort, if any, has been made to investigate the cellular effect of res- veratrol treatment on intrinsic neuronal properties. Materials and Methods This experimental study was performed to examine the acute effects of resveratrol (100 µM) on the intrinsic evoked responses of rat Cornu Ammonis (CA1) pyramidal neurons in brain slices, using whole cell patch clamp re- cording under current clamp conditions. Results Findings showed that resveratrol treatment caused dramatic changes in evoked responses of pyramidal neurons. Its treatment induced a significant (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c6a7bebbf4f9c72fc2fd7fa4ce592c1b http://celljournal.org/web/journal/article/991/download Zobrazit plný text záznamu Plný text ve formátu PDF