Developmental origin and maintenance of distinct testicular macrophage populations
| Autor: | Mossadegh-Keller, Noushin, Gentek, Rebecca, Gimenez, Gregory, Bigot, Sylvain, Mailfert, Sebastien, Sieweke, Michael H. |
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| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Max Delbrück Centrum für Molekulare Medizin (MDC), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), ANR-11-BSV3-0026,ReNEW,Mecanismes d'autorenouvellement des macrophages differencies(2011), European Project: 695093,MacAge, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtzgemeinschaft, 13125 Berlin, Germany |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research Testicular macrophage populations Cell Proliferation/physiology Real-Time Polymerase Chain Reaction Mice Testis Animals Immunity Cellular/physiology Spermatogenesis Testis/cytology Research Articles Cell Proliferation Immunity Cellular Gene Expression Profiling Macrophages Stem Cells Immune cells Brief Definitive Report Macrophages/cytology Flow Cytometry Testicular macrophages (tM phi) Stem Cells/physiology Mice Inbred C57BL [SDV.IMM]Life Sciences [q-bio]/Immunology Spermatogenesis/physiology |
| Zdroj: | Journal of Experimental Medicine Journal of Experimental Medicine, 2017, 214 (10), pp.2829-2841. ⟨10.1084/jem.20170829⟩ Journal of Experimental Medicine, Rockefeller University Press, 2017, 214 (10), pp.2829-2841. ⟨10.1084/jem.20170829⟩ The Journal of Experimental Medicine Mossadegh-Keller, N, Gentek, R, Gimenez, G, Bigot, S, Mailfert, S & Sieweke, M H 2017, ' Developmental origin and maintenance of distinct testicular macrophage populations ', Journal of Experimental Medicine, vol. 214, no. 10, pp. 2829-2841 . https://doi.org/10.1084/jem.20170829 |
| ISSN: | 0022-1007 1540-9538 |
| DOI: | 10.1084/jem.20170829⟩ |
| Popis: | Mossadegh-Keller et al. show distinct origin of two different testicular macrophage populations during the postnatal development. Embryonic precursors give rise exclusively to the interstitial macrophage population, whereas peritubular macrophages derive from bone marrow progenitors only postnatally. Surprisingly, both macrophage populations display a remarkable long life span. Testicular macrophages (tMφ) are the principal immune cells of the mammalian testis. Beyond classical immune functions, they have been shown to be important for organogenesis, spermatogenesis, and male hormone production. In the adult testis, two different macrophage populations have been identified based on their distinct tissue localization and morphology, but their developmental origin and mode of homeostatic maintenance are unknown. In this study, we use genetic lineage–tracing models and adoptive transfer protocols to address this question. We show that embryonic progenitors give rise to the interstitial macrophage population, whereas peritubular macrophages are exclusively seeded postnatally in the prepuberty period from bone marrow (BM)–derived progenitors. As the proliferative capacity of interstitial macrophages declines, BM progenitors also contribute to this population. Once established, both the peritubular and interstitial macrophage populations exhibit a long life span and a low turnover in the steady state. Our observations identify distinct developmental pathways for two different tMφ populations that have important implications for the further dissection of their distinct roles in organ homeostasis and testicular function. |
| Databáze: | OpenAIRE |
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