Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging
| Autor: | Duce, Suzanne L., Weir-McCall, Jonathan R., Gandy, Stephen J., Matthew, Shona Z., Cassidy, Deirdre B., McCormick, Lynne, Rauchhaus, Petra, Looker, Helen, Colhoun, Helen M., Houston, J. Graeme |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Heart Diseases Endocrinology Diabetes and Metabolism T2DM Contrast Media Magnetic Resonance Imaging Cine Risk Assessment Severity of Illness Index Predictive Value of Tests Risk Factors Type 2 diabetes mellitus Humans Whole Body Imaging cardiovascular diseases CMR Atheroma score Original Investigation Aged Whole body MRI LVA Magnetic resonance angiography Middle Aged Cardiovascular disease Atherosclerosis Diabetes Mellitus Type 2 Case-Control Studies WB CVMR Female Cardiology and Cardiovascular Medicine Diabetic Angiopathies |
| Zdroj: | Duce, S L, Weir-McCall, J R, Gandy, S J, Matthew, S Z, Cassidy, D B, McCormick, L, Rauchhaus, P, Looker, H, Colhoun, H M & Houston, J G 2015, ' Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging ', Cardiovascular diabetology, vol. 14, pp. 122 . https://doi.org/10.1186/s12933-015-0284-2 Cardiovascular Diabetology |
| DOI: | 10.1186/s12933-015-0284-2 |
| Popis: | Background Whole body cardiovascular MR (WB CVMR) combines whole body angiography and cardiac MR assessment. It is accepted that there is a high disease burden in patients with diabetes, however the quantification of the whole body atheroma burden in both arterial and cardiac disease has not been previously reported. In this study we compare the quantified atheroma burden in those individuals with and without diabetes by clinical cardiovascular disease (CVD) status. Methods 158 participants underwent WB CVMR, and were categorised into one of four groups: (1) type 2 diabetes mellitus (T2DM) with CVD; (2) T2DM without CVD; (3) CVD without T2DM; (4) healthy controls. The arterial tree was subdivided into 31 segments and each scored according to the degree of stenosis. From this a standardised atheroma score (SAS) was calculated. Cardiac MR and late gadolinium enhancement images of the left ventricle were obtained for assessment of mass, volume and myocardial scar assessment. Results 148 participants completed the study protocol—61 % male, with mean age of 64 ± 8.2 years. SAS was highest in those with cardiovascular disease without diabetes [10.1 (0–39.5)], followed by those with T2DM and CVD [4 (0–41.1)], then those with T2DM only [3.23 (0–19.4)] with healthy controls having the lowest atheroma score [2.4 (0–19.4)]. Both groups with a prior history of CVD had a higher SAS and left ventricular mass than those without (p |
| Databáze: | OpenAIRE |
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