Patients with newly diagnosed rheumatoid arthritis are at increased risk of diabetes mellitus: an observational cohort study
| Autor: | Emamifar, Amir, Levin, Klaus, Jensen Hansen, Inger Marie |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
rheumatoid arthritis
lcsh:Immunologic diseases. Allergy Adult Aged 80 and over Male lcsh:Internal medicine Middle Aged rheumatoid factor Arthritis Rheumatoid Cohort Studies Young Adult Diabetes mellitus Anti-CCP Risk Factors Diabetes Mellitus Prevalence DAS28 RF Humans Female Rheumatoid arthritis lcsh:RC31-1245 lcsh:RC581-607 Child Aged |
| Zdroj: | Acta Reumatológica Portuguesa, Vol 2017, Iss 4, Pp 310-317 (2017) Emamifar, A, Levin, K & Jensen Hansen, I M 2017, ' Patients with newly diagnosed Rheumatoid Arthritis are at increased risk of Diabetes Mellitus : An Observational Cohort study ', Acta Reumatologica Portuguesa, vol. 42, no. 4, pp. 310-317 . < http://www.actareumatologica.com/article_abstract.php?id=1187 > |
| ISSN: | 2184-8777 |
| Popis: | Aims: To reveal the prevalence of diabetes mellitus (DM) in patients with newly diagnosed rheumatoid arthritis (RA) and evaluate the association between cli nical cha - racteristics of RA and DM, as well as, treatment response in newly diagnosed RA patients with DM. Methods: Newly diagnosed, adult, RA patients, who were registered in Danish Danbio since 1st January 2010, were included. Patients' demographics, serology results including rheumatoid factor (RF), anti-cyclic citrullina - ted peptide antibody (anti-CCP) and antinuclear antibo - dy (ANA), as well as, disease activity score in 28 joints- -C-reactive protein (DAS28-CRP), at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation, were extracted from Danbio Regis try. To reveal the presence of DM, patients' electronic medi cal records were reviewed. The prevalence of DM in our patients was compared (using an age- and gender-matched analysis) with that expected from Danish popu lation. Results: of 439 included patients, 60.1% were female, mean of age 64.6±15.0 years and RA disease duration 2.6±1.7 years. Prevalence of DM was 57/439 (12.9%), herein type II DM 52 (91.2%) and type I DM 5 (8.8%). Except for two patients, diagnosis of DM was esta - blished prior to the diagnosis of RA. The prevalence of DM in newly diagnosed RA patients of all ages was signi ficantly increased versus that expected from Da - nish population (RR=2.21, CI=1.40-3.42, P < 0.001). In addition, prevalence of DM was significantly increa - sed with more than twice of the expected for RA patients aged 65-84. Both genders showed increased risk of DM after subgroup analysis. The presence of DM in RA patients was significantly associated with age (P < 0.001) and RA disease duration ≥4 years (P =0.05). We did not find any significant associations between presence of DM and gender, RF, anti-CCP, as well as, ANA. Additionally, presence of DM in the RA patients was not a negative predictor of treatment response measured by the European League Against Rheumatism (EULAR) response criteria and DDAS28-CRP. Conclusion: Newly diagnosed RA patients are at hi gher risk of DM (13% versus 5.7% in Denmark), and a high index of suspicion must be kept. |
| Databáze: | OpenAIRE |
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