Partial dysfunction of Treg activation in sickle cell disease
| Autor: | Benoît, Vingert, Marie, Tamagne, Maxime, Desmarets, Sadaf, Pakdaman, Rahma, Elayeb, Anoosha, Habibi, Françoise, Bernaudin, Frédéric, Galacteros, Philippe, Bierling, France, Noizat-Pirenne, José Laurent, Cohen, José, Cohen |
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| Přispěvatelé: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Etablissement Français du Sang [Île-de-France Mondor], Unité des Maladies Génétiques du Globule Rouge [CHU Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Référence de Drépanocytose [CHI Créteil] (CRD), Centre Hospitalier Intercommunal de Créteil (CHIC), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CIC - Biotherapie - CHU Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Vingert, Benoit |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Receptors CCR7 Erythrocytes [SDV.IMM] Life Sciences [q-bio]/Immunology chemical and pharmacologic phenomena hemic and immune systems Anemia Sickle Cell HLA-DR Antigens Middle Aged T-Lymphocytes Regulatory Young Adult Phenotype Antigens CD hemic and lymphatic diseases Blood Group Incompatibility Blood Group Antigens [SDV.IMM]Life Sciences [q-bio]/Immunology Humans CTLA-4 Antigen Female |
| Zdroj: | American Journal of Hematology American Journal of Hematology, Wiley, 2013, 89, pp.261-266. ⟨10.1002/ajh.23629⟩ |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.23629⟩ |
| Popis: | International audience; Sickle cell disease (SCD) is a chronic inflammatory disease associated with multiple organ damage, chronic anemia, and infections. SCD patients have a high rate of alloimmunization against red blood cells (RBCs) following transfusion and may develop autoimmune diseases. Studies in mouse models have suggested that regulatory T cells (Treg) play a role in alloimmunization against RBC antigens. We characterized the phenotype and function of the Treg cell population in a homogeneous cohort of transfused SCD patients. We found that the distribution of Treg subpopulations differed significantly between SCD patients and healthy blood donors. SCD patients have a particular Treg phenotype, with strong CTLA-4 and CD39 expression and weak HLA-DR and CCR7 expression. Finally, we show that this particular phenotype is related to SCD rather than alloimmunization status. Indeed, we observed no difference in Treg phenotype or function in vitro using autologous feeder cells between strong and weak responders to alloimmunization. |
| Databáze: | OpenAIRE |
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