A herbal antifungal formulation of Thymus serpillum, Origanum vulgare and Rosmarinus officinalis for treating ovine dermatophytosis due to Trichophyton mentagrophytes
| Autor: | Linda, Mugnaini, Simona, Nardoni, Luisa, Pistelli, Michele, Leonardi, Lorella, Giuliotti, Maria N, Benvenuti, Francesca, Pisseri, Francesca, Mancianti |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Sheep Thymus serpillum Chemistry Pharmaceutical carvacrol Sheep Diseases Microbial Sensitivity Tests Rosmarinus Disease Outbreaks Thymus Plant Trichophyton mentagrophytes Tinea Trichophyton Essential oils Origanum thymol Monoterpenes Oils Volatile Animals Cymenes Dermatomycoses Plant Preparations Origanum vulgare |
| Popis: | A number of herbal products with anti-inflammatory, antiseptic and antimycotic properties are available for dermatological usage. The successful treatment of 13 sheep affected by ringworm due to Trichophyton mentagrophytes with a mixture consisting of essential oils (EOs) of Thymus serpillum 2%, Origanum vulgare 5% and Rosmarinus officinalis 5% in sweet almond (Prunus dulcis) oil. The effectiveness of EOs and of the major components of the mixture (thymol, carvacrol, 1,8 cineole, α-pinene, p-cymene, γ-terpinene) against the fungal clinical isolate was evaluated by a microdilution test. Thirteen animals were topically administered with the mixture twice daily for 15 days. The other sheep were administered with a conventional treatment (seven animals) or left untreated (two animals). Minimum inhibitory concentration (MIC) values were 0.1% for T. serpillum, 0.5% for O. vulgare, 2.5% for I. verum and 5% for both R. officinalis and C. limon. Thymol and carvacrol showed MICs of 0.125% and 0.0625%. A clinical and aetiological cure was obtained at the end of each treatment regimen in only the treated animals. Specific antimycotic drugs licenced for food-producing sheep are not available within the European Community. The mixture tested here appeared to be a versatile tool for limiting fungal growth. |
| Databáze: | OpenAIRE |
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