4pp Mucocutaneous manifestations of methotrexate toxicity
| Autor: | Bruno, Ferrari, Nora, Kogan, Rosana C, Veira, Paula C, Luna, Margarita, Larralde, María Gabriela, Cuesta, Pamela, Díaz, María Verónica, Rossi, Italo, Aloise |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Aged
80 and over Male lcsh:Immunologic diseases. Allergy folinic acid lcsh:R toxicity lcsh:Medicine psoriasis Middle Aged ulcerations methotrexate lcsh:Infectious and parasitic diseases Diagnosis Differential Skin Ulcer Humans Female lcsh:RC109-216 Drug Eruptions lcsh:RC581-607 Immunosuppressive Agents Aged Retrospective Studies |
| Zdroj: | Medicina (Buenos Aires), Vol 78, Iss 1, Pp 50-53 (2018) |
| ISSN: | 1669-9106 0025-7680 |
| Popis: | Methotrexate is an antimetabolite analog to folic acid that competitively inhibits the enzyme dihydrofolate reductase and thymidylate synthetase, essential for the synthesis of DNA and RNA. It is widely used in dermatology and its adverse effects on the skin and mucous membranes are varied, including mild and severe reactions. The appearance of erosions and skin ulcers as a manifestation of methotrexate cytotoxicity are quite infrequent. These would represent an early cutaneous sign of pancytopenia due to marrow toxicity secondary to this drug. In most of the cases there are cutaneous diseases prior to ulceration, mainly psoriasis. In the absence of underlying dermatitis, the presence of ulcerations is very rare. We present eight cases of patients with cutaneous signs of methotrexate poisoning, with and without previous dermatoses. Most of them associated mucositis and bone marrow involvement. Treatment guidelines are recommended. |
| Databáze: | OpenAIRE |
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