Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments
| Autor: | Maria Luisa, Calabrò, Nayana, Lazzari, Giulia, Rigotto, Marco, Tonello, Antonio, Sommariva |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
pseudomyxoma peritonei
Cell Plasticity epithelial-mesenchymal transition EMT Disease Management Review PMP hyperthermic intraperitoneal chemotherapy lcsh:Chemistry epithelial-mesenchymal plasticity lcsh:Biology (General) lcsh:QD1-999 Osteogenesis CRS/HIPEC Animals Humans cytoreductive surgery Disease Susceptibility EMP lcsh:QH301-705.5 Biomarkers Peritoneal Neoplasms |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 9120, p 9120 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The mechanisms by which neoplastic cells disseminate from the primary tumor to metastatic sites, so-called metastatic organotropism, remain poorly understood. Epithelial–mesenchymal transition (EMT) plays a role in cancer development and progression by converting static epithelial cells into the migratory and microenvironment-interacting mesenchymal cells, and by the modulation of chemoresistance and stemness of tumor cells. Several findings highlight that pathways involved in EMT and its reverse process (mesenchymal–epithelial transition, MET), now collectively called epithelial–mesenchymal plasticity (EMP), play a role in peritoneal metastases. So far, the relevance of factors linked to EMP in a unique peritoneal malignancy such as pseudomyxoma peritonei (PMP) has not been fully elucidated. In this review, we focus on the role of epithelial–mesenchymal dynamics in the metastatic process involving mucinous neoplastic dissemination in the peritoneum. In particular, we discuss the role of expression profiles and phenotypic transitions found in PMP in light of the recent concept of EMP. A better understanding of EMP-associated mechanisms driving peritoneal metastasis will help to provide a more targeted approach for PMP patients selected for locoregional interventions involving cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. |
| Databáze: | OpenAIRE |
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