Enlarged perivascular spaces and cerebral small vessel disease

Autor: Potter, Gillian M., Doubal, Fergus N., Caroline Jackson, Chappell, Francesca M., Sudlow, Cathie L., Dennis, Martin S., Wardlaw, Joanna M.
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Stroke
Potter, G M, Doubal, F N, Jackson, C, Chappell, F M, Sudlow, C, Dennis, M S & Wardlaw, J M 2015, ' Enlarged perivascular spaces and cerebral small vessel disease ', International Journal of Stroke, vol. 10, no. 3, pp. 376-381 . https://doi.org/10.1111/ijs.12054
ResearcherID
ISSN: 1747-4949
1747-4930
DOI: 10.1111/ijs.12054
Popis: Background and aims Enlarged perivascular spaces (also known as Virchow–Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel as opposed to general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged perivascular spaces and ischemic stroke subtype, other markers of small vessel disease, and common vascular risk factors. Methods We prospectively recruited patients with acute stroke, diagnosed and subtyped by a stroke physician using clinical features and brain magnetic resonance imaging. A neuroradiologist rated basal ganglia and centrum semiovale enlarged perivascular spaces on a five-point scale, white matter lesions, recent and old infarcts, and cerebral atrophy. We assessed associations between basal ganglia-, centrum semiovale- and total (combined basal ganglia and centrum semiovale) enlarged perivascular spaces, stroke subtype, white matter lesions, atrophy, and vascular risk factors. Results Among 298 patients (mean age 68 years), after adjusting for vascular risk factors and white matter lesions, basal ganglia–enlarged perivascular spaces were associated with increasing age (P = 0·001), centrum semiovale–enlarged perivascular spaces (P
Databáze: OpenAIRE
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