Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya

Autor: Halliday, Jo E.B., Knobel, Darryn L., Agwanda, Bernard F., Bai, Ying, Breiman, Robert F., Cleaveland, Sarah, Njenga, M.Kariuki, Kosoy, Michael
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003608 (2015)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted.
Author Summary Bartonella are bacteria that infect many different mammal species and can cause illness in people. Several Bartonella species carried by rodents cause disease in humans but little is known about their distribution or the importance of bartonellosis as a cause of human illness. Data from Africa are particularly scarce. This study involved trapping of rodents and other small mammals at two sites in Kenya: Asembo, a rural area in Western Kenya, and Kibera, an informal urban settlement in Nairobi. Blood samples were collected from trapped animals to detect and characterize the types of Bartonella carried. At the Kibera site over half of the trapped rats were infected with Bartonella very similar to human pathogenic strains isolated from rats from other global regions. In Asembo, Bartonella were detected in four of the five animal species trapped and these Bartonella were less similar to previously identified isolates. All of the small mammals included in this study were trapped in or around human habitations. The data from this study show that Bartonella that can cause human illness are carried by the small mammals at these two sites and indicate that the public health impacts of human bartonellosis should be investigated.
Databáze: OpenAIRE
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