High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats

Autor: Lacombe, Emilie, Carcenac, Carole, Boulet, Sabrina, Feuerstein, Claude, Bertrand, Anne, Poupard, Annie, Savasta, Marc
Přispěvatelé: Savasta, Marc, Neurosciences, neurologie et psychiatrie - Dynamique et plasticité des interactions cellulaires et moléculaires au sein des ganglions de la base qui sous-tendent les troubles du mouvement: noyau subthalamique et maladie de Parkinson - - DYPLAG2005 - ANR-05-NEUR-0013 - NEURO - VALID, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Institut National de la Santé et de la Recherche Médicale, Ministère de la Recherche et des Nouvelles Technologies, Région Rhône-Alpes (Cluster n°11), ANR-05-NEUR-0013,DYPLAG,Dynamique et plasticité des interactions cellulaires et moléculaires au sein des ganglions de la base qui sous-tendent les troubles du mouvement: noyau subthalamique et maladie de Parkinson(2005)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
MESH: Rats
Dopamine
Microdialysis
Dopamine Agents
MESH: Dopamine Agents
MESH: Rats
Sprague-Dawley
MESH: Dopamine
MESH: Dihydroxyphenylalanine
Synaptic Transmission
Article
Rats
Sprague-Dawley
Subthalamic Nucleus
MESH: Synaptic Transmission
MESH: Homovanillic Acid
Animals
MESH: Animals
MESH: Microdialysis
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH: Denervation
Oxidopamine
MESH: Subthalamic Nucleus
MESH: Electric Stimulation
Homovanillic Acid
MESH: 3
4-Dihydroxyphenylacetic Acid
Denervation
MESH: Male
Electric Stimulation
nervous system diseases
Dihydroxyphenylalanine
Rats
MESH: Oxidopamine
MESH: Extracellular Space
Neostriatum
MESH: Neostriatum
nervous system
Data Interpretation
Statistical
3
4-Dihydroxyphenylacetic Acid
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Extracellular Space
MESH: Data Interpretation
Statistical
Zdroj: European Journal of Neuroscience
European Journal of Neuroscience, Wiley, 2007, 26 (6), pp.1670-80. ⟨10.1111/j.1460-9568.2007.05747.x⟩
ISSN: 0953-816X
1460-9568
DOI: 10.1111/j.1460-9568.2007.05747.x⟩
Popis: International audience; High-frequency stimulation of the subthalamic nucleus (STN-HFS) is a powerful approach for treating the motor symptoms of Parkinson's disease (PD). It results in clinical improvement in patients with PD, further reducing the l-3,4-dihydroxyphenylalanine (L-DOPA) requirement and thus L-DOPA-induced dyskinesia. However, it remains unclear how STN-HFS modifies the response to L-DOPA. We investigated the effect of STN-HFS on striatal extracellular concentrations of dopamine and its metabolites following acute L-DOPA administration in intact or partially dopaminergic denervated (DA-PL) rats. L-DOPA treatment significantly increased striatal dopamine levels in intact and DA-PL animals, with the maximal effect observed 1 h after L-DOPA injection. This increase was more pronounced in DA-PL rats (ipsilateral to the lesion) than in intact animals. It remained fairly stable 1 h after the maximal effect of L-DOPA and then decreased towards basal values. STN-HFS in intact rats had no effect on the maximal L-DOPA-induced increase in striatal extracellular dopamine concentration or the return to basal values, the profiles observed being similar to those for non-stimulated intact animals. Conversely, STN-HFS amplified the L-DOPA-induced increase in striatal dopamine levels during the stimulation period (1 h) in DA-PL rats and this increase was sustained throughout the post-stimulation period (2.5 h), without the return to basal levels observed in stimulated intact and non-stimulated rats. These new neurochemical data suggest that STN-HFS interferes with L-DOPA effects, probably synergically, by stabilizing dopamine levels in the striatum and shed light on the mechanisms of STN-HFS in PD.
Databáze: OpenAIRE
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