Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Autor: Samuel E, Jones, Jacqueline M, Lane, Andrew R, Wood, Vincent T, van Hees, Jessica, Tyrrell, Robin N, Beaumont, Aaron R, Jeffries, Hassan S, Dashti, Melvyn, Hillsdon, Katherine S, Ruth, Marcus A, Tuke, Hanieh, Yaghootkar, Seth A, Sharp, Yingjie, Jie, William D, Thompson, Jamie W, Harrison, Amy, Dawes, Enda M, Byrne, Henning, Tiemeier, Karla V, Allebrandt, Jack, Bowden, David W, Ray, Rachel M, Freathy, Anna, Murray, Diego R, Mazzotti, Philip R, Gehrman, Debbie A, Lawlor, Timothy M, Frayling, Martin K, Rutter, David A, Hinds, Richa, Saxena, Michael N, Weedon
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Jones, S E, Lane, J M, Wood, A R, van Hees, V T, Tyrrell, J, Beaumont, R N, Jeffries, A R, Dashti, H S, Hillsdon, M, Ruth, K S, Tuke, M A, Yaghootkar, H, Sharp, S A, Jie, Y, Thompson, W D, Harrison, J W, Dawes, A, Byrne, E M, Tiemeier, H, Allebrandt, K V, Bowden, J, Ray, D W, Freathy, R M, Murray, A, Mazzotti, D R, Gehrman, P R, Lawlor, D A, Frayling, T M, Rutter, M K, Hinds, D A, Saxena, R & Weedon, M N 2019, ' Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms ', Nature Communications, vol. 10, no. 1, 343 . https://doi.org/10.1038/s41467-018-08259-7
Nature Communications
ISSN: 2041-1723
Popis: Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
GWAS have previously found 24 genomic loci associated with chronotype, an individual’s preference for early or late sleep timing. Here, the authors identify 327 additional loci in a sample of 697,828 individuals and further explore the relationships of chronotype with metabolic and psychiatric diseases.
Databáze: OpenAIRE
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