Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases

Autor: Liu, Jian-Miao, Garcia-Alvarez, Maria-Concepcion, Bignon, Jerome, Kusinski, Michal, Kuzdak, Krzysztof, Riches, Andrew, Wdzieczak-Bakala, Joanna
Přispěvatelé: Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Rok vydání: 2010
Předmět:
Zdroj: Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences, Wiley, 2010, 1194, pp.53-59. ⟨10.1111/j.1749-6632.2010.05488.x⟩
ISSN: 1749-6632
0077-8923
DOI: 10.1111/j.1749-6632.2010.05488.x⟩
Popis: International audience; The natural tetrapeptide acetyl-ser-asp-lys-pro (AcSDKP) is formed in vivo by enzymatic cleavage of the N terminus of thymosin beta4 by prolyl oligopeptidase (POP). Recently, AcSDKP was shown to promote angiogenesis. Because of the critical role of neovascularization in cancer development, the levels of AcSDKP and POP activity in a number of different malignant tissues were investigated. Our studies revealed that AcSDKP levels were markedly elevated in neoplastic diseases including hematologic malignancies and solid neoplasms. Consistent with this finding, the enhanced activity of POP was also detected in all analyzed specimens of cancer tissues. Both these novel findings are in concert with the previously reported overexpression of thymosin beta4 in a large variety of malignant tumors and with its potential role in cancerogenesis. The physiological relevance of these findings awaits further studies; however, our first results strongly suggest a key role for AcSDKP in the pathogenesis of cancer.
Databáze: OpenAIRE
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